Erich WICHMAN - BIOBANQUES May 19, 2016
Biobanking National Infrastructure Meeting
Quality matters: Improving the quality of biological resources
Pre-analytic processing of liquid samples in population cohorts in Germany
Linkage of high quality biosamples with detailed data from medical examinations, questionnaires and interviews offers great opportunities for research. This is particularly true for large scale prospective epidemiological studies with long observation periods, like the KORA Cohort in Augsburg and the German National Cohort (GNC). For the GNC 200.000 randomly selected adults will be recruited by 18 study centers and will be followed-up for 20-30 years. In addition to the extensive basic examination protocol, followed by reassessment examinations and follow-up questionnaires, the biorepository is a cornerstone of the GNC.The GNC biorepository will comprise more than 20 million aliquots of plasma, serum, erythrocytes, lymphocytes, urine, saliva, nasal swabs and stool. Preanalytics and aliquoting are performed locally in the study centers and are highly standardized and extensively automated. All samples are stored at -80°C and -180°C respectively. A laboratory information system documents all processing steps and storage locations. Access to data and biosamples will be granted to researchers within and outside Germany. Experience with already existing epidemiological biobanks like KORA shows impressive results, especially with regard to genetic research as well as post-genomics (e.g. transcriptomics, metabolomics, epigenomics). Previous success stories explain the strongly increased demand for data and biosamples from thepopulation. These resources will become even more important for biomedical research in the future.
THURSDAY MAY 19, 2016