- Bill Ollier
- Martin Yuille
Bill OLLIER and Martin YUILLE - BIOBANQUES May 18, 2016
Biobanking National Infrastructure Meeting
Quality matters: Improving the quality of biological resources
Session 2: The present and future of biobanking / Session 2B: Next Generation Biobanking
Bill OLLIER, Martin YUILLE
Precision Public Health: the essential role of healthcare-integrated biobanks.
First talk: Precision Public Health and an “engine” for health improvement.
Second talk: From theory into practise.
Abstract: Precision Public Health (PPH) builds on the concept of Predictive Preventive Personalised Participatory (P4) medicine by applying it in the field of Public Health implemented via primary care. PPH aims at prevention (preventing or delaying risk factor exposure) using individual risk profiles developed for all members of the population. Whereas Precision Medicine in the UK refers to the development of more precisely targeted medicines including new medicines, PPH refers to the development of Public Health policy and practise to achieve universal prevention by including new tools such as biomarkers in order yo specify individualised health improvement interventions.
For practical reasons, a PPH pathfinder project starts with a selective prevention strategy but the goal is universal prevention. While P4 medicine is also preventive in its intentions, it is seen as being driven by the consumer. PPH is driven by public policy. It therefore has a good prospect of achieving improved population health regardless of socio-economic and educational status. The universal principles of the UK national Health Service provide a critical policy element that allows PPH.
We are developing a PPH pathfinder project for Greater Manchester (GM). Recent decentralisation of national health funding to GM will facilitate evidence-based population health improvement by enabling greater integration across local government services (health, Public Health, social care but also education, transport, housing). A key policy driver will be the adoption of obesity onto the Community Risk Register. An obesity epidemic exists in the UK and, by recognising this on the risk register, policies and practices across the range of local government responsibilities can be reviewed and modified to address the epidemic.
The PPH pathfinder project should be implemented in one part of GM (Salford) where the essential infrastructure for PPH already exists. This infrastructure comprises a hospital-based high-throughput quality-managed biobank, integrated electronic healthrecords across all of primary and secondary care and a suite of health improvement interventions. For the pathfinder, about 10,000 participants (18 -49 years old) will be recruited via family doctors to the project. They will consent to research, provide a sample, undergo a health check and receive feedback. This feedback will use biomarker and other data to calculate an individual’s current risk of chronic disease including obesity-related disease. This risk information will be provided along with education on suitable preventive action and offers of access to health improvement interventions. Taken together, the project will reduce exposure torisk factors and thus improve health. It will also provide a platform for basic, translational and implementation research for improved PPH and, simultaneously, for Precision Medicine.
TUESDAY MAY 17, 2016